Speaking to foreign policy advisers in Moscow, Mr Lavrov referred to calls for sanctions “that will destroy the economy and cause public protests”.
On Thursday, President Vladimir Putin said Moscow must guard against a “colour revolution”.
Russia denies arming Ukrainian rebels or sending Russian troops there.
Western sanctions were first imposed when Russia annexed Ukraine’s region of Crimea in March following a controversial referendum.
Further measures have been added since, targeting senior Russian officials as well as defence firms, banks and the country’s oil industry.
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