The leader of the Islamic State group blew himself up along with members of his family as American forces raided his Syria hideout Thursday, the U.S. said — the second time in three years the United States has taken out a leader of the violent group that has been struggling for resurgence with deadly attacks in the region.

President Joe Biden announced the overnight raid by American special operations forces, which U.S. officials called a “significant blow” to the radical militant organization.